diff --git a/src/pow.cpp b/src/pow.cpp
index 0f54aaec0f7..907d378741d 100644
--- a/src/pow.cpp
+++ b/src/pow.cpp
@@ -139,7 +139,7 @@ bool PermittedDifficultyTransition(const Consensus::Params& params, int64_t heig
 // the most significant bit of the last byte of the hash is set.
 bool CheckProofOfWork(uint256 hash, unsigned int nBits, const Consensus::Params& params)
 {
-    if constexpr (G_FUZZING) return (hash.data()[31] & 0x80) == 0;
+    if (EnableFuzzDeterminism()) return (hash.data()[31] & 0x80) == 0;
     return CheckProofOfWorkImpl(hash, nBits, params);
 }
 
diff --git a/src/test/fuzz/fuzz.cpp b/src/test/fuzz/fuzz.cpp
index 30766700b9d..77341898536 100644
--- a/src/test/fuzz/fuzz.cpp
+++ b/src/test/fuzz/fuzz.cpp
@@ -147,10 +147,18 @@ static void initialize()
         std::cerr << "No fuzz target compiled for " << g_fuzz_target << "." << std::endl;
         std::exit(EXIT_FAILURE);
     }
-    if constexpr (!G_FUZZING) {
-        std::cerr << "Must compile with -DBUILD_FOR_FUZZING=ON to execute a fuzz target." << std::endl;
+    if constexpr (!G_FUZZING_BUILD && !G_ABORT_ON_FAILED_ASSUME) {
+        std::cerr << "Must compile with -DBUILD_FOR_FUZZING=ON or in Debug mode to execute a fuzz target." << std::endl;
         std::exit(EXIT_FAILURE);
     }
+    if (!EnableFuzzDeterminism()) {
+        if (std::getenv("FUZZ_NONDETERMINISM")) {
+            std::cerr << "Warning: FUZZ_NONDETERMINISM env var set, results may be inconsistent with fuzz build" << std::endl;
+        } else {
+            g_enable_dynamic_fuzz_determinism = true;
+            assert(EnableFuzzDeterminism());
+        }
+    }
     Assert(!g_test_one_input);
     g_test_one_input = &it->second.test_one_input;
     it->second.opts.init();
diff --git a/src/test/util/random.cpp b/src/test/util/random.cpp
index d75f1ef8a6b..90ddf66ca41 100644
--- a/src/test/util/random.cpp
+++ b/src/test/util/random.cpp
@@ -25,7 +25,7 @@ void SeedRandomStateForTest(SeedRand seedtype)
     // no longer truly random. It should be enough to get the seed once for the
     // process.
     static const auto g_ctx_seed = []() -> std::optional<uint256> {
-        if constexpr (G_FUZZING) return {};
+        if (EnableFuzzDeterminism()) return {};
         // If RANDOM_CTX_SEED is set, use that as seed.
         if (const char* num{std::getenv(RANDOM_CTX_SEED)}) {
             if (auto num_parsed{uint256::FromUserHex(num)}) {
@@ -40,7 +40,7 @@ void SeedRandomStateForTest(SeedRand seedtype)
     }();
 
     g_seeded_g_prng_zero = seedtype == SeedRand::ZEROS;
-    if constexpr (G_FUZZING) {
+    if (EnableFuzzDeterminism()) {
         Assert(g_seeded_g_prng_zero); // Only SeedRandomStateForTest(SeedRand::ZEROS) is allowed in fuzz tests
         Assert(!g_used_g_prng);       // The global PRNG must not have been used before SeedRandomStateForTest(SeedRand::ZEROS)
     }
diff --git a/src/test/util/setup_common.cpp b/src/test/util/setup_common.cpp
index 87f0b31cad8..82bbc4adcba 100644
--- a/src/test/util/setup_common.cpp
+++ b/src/test/util/setup_common.cpp
@@ -112,7 +112,7 @@ static void ExitFailure(std::string_view str_err)
 BasicTestingSetup::BasicTestingSetup(const ChainType chainType, TestOpts opts)
     : m_args{}
 {
-    if constexpr (!G_FUZZING) {
+    if (!EnableFuzzDeterminism()) {
         SeedRandomForTest(SeedRand::FIXED_SEED);
     }
     m_node.shutdown_signal = &m_interrupt;
@@ -203,7 +203,7 @@ BasicTestingSetup::~BasicTestingSetup()
 {
     m_node.ecc_context.reset();
     m_node.kernel.reset();
-    if constexpr (!G_FUZZING) {
+    if (!EnableFuzzDeterminism()) {
         SetMockTime(0s); // Reset mocktime for following tests
     }
     LogInstance().DisconnectTestLogger();
@@ -229,8 +229,9 @@ ChainTestingSetup::ChainTestingSetup(const ChainType chainType, TestOpts opts)
         m_node.scheduler->m_service_thread = std::thread(util::TraceThread, "scheduler", [&] { m_node.scheduler->serviceQueue(); });
         m_node.validation_signals =
             // Use synchronous task runner while fuzzing to avoid non-determinism
-            G_FUZZING ? std::make_unique<ValidationSignals>(std::make_unique<util::ImmediateTaskRunner>()) :
-                        std::make_unique<ValidationSignals>(std::make_unique<SerialTaskRunner>(*m_node.scheduler));
+            EnableFuzzDeterminism() ?
+                std::make_unique<ValidationSignals>(std::make_unique<util::ImmediateTaskRunner>()) :
+                std::make_unique<ValidationSignals>(std::make_unique<SerialTaskRunner>(*m_node.scheduler));
         {
             // Ensure deterministic coverage by waiting for m_service_thread to be running
             std::promise<void> promise;
@@ -255,7 +256,7 @@ ChainTestingSetup::ChainTestingSetup(const ChainType chainType, TestOpts opts)
             .notifications = *m_node.notifications,
             .signals = m_node.validation_signals.get(),
             // Use no worker threads while fuzzing to avoid non-determinism
-            .worker_threads_num = G_FUZZING ? 0 : 2,
+            .worker_threads_num = EnableFuzzDeterminism() ? 0 : 2,
         };
         if (opts.min_validation_cache) {
             chainman_opts.script_execution_cache_bytes = 0;
diff --git a/src/util/check.cpp b/src/util/check.cpp
index 1430c0e8e29..9f07fbe4780 100644
--- a/src/util/check.cpp
+++ b/src/util/check.cpp
@@ -33,3 +33,5 @@ void assertion_fail(std::string_view file, int line, std::string_view func, std:
     fwrite(str.data(), 1, str.size(), stderr);
     std::abort();
 }
+
+std::atomic<bool> g_enable_dynamic_fuzz_determinism{false};
diff --git a/src/util/check.h b/src/util/check.h
index efc78915a9e..f7dea5a3c2e 100644
--- a/src/util/check.h
+++ b/src/util/check.h
@@ -7,19 +7,44 @@
 
 #include <attributes.h>
 
+#include <atomic>
 #include <cassert> // IWYU pragma: export
 #include <stdexcept>
 #include <string>
 #include <string_view>
 #include <utility>
 
-constexpr bool G_FUZZING{
+constexpr bool G_FUZZING_BUILD{
 #ifdef FUZZING_BUILD_MODE_UNSAFE_FOR_PRODUCTION
     true
 #else
     false
 #endif
 };
+constexpr bool G_ABORT_ON_FAILED_ASSUME{
+#ifdef ABORT_ON_FAILED_ASSUME
+    true
+#else
+    false
+#endif
+};
+
+extern std::atomic<bool> g_enable_dynamic_fuzz_determinism;
+
+inline bool EnableFuzzDeterminism()
+{
+    if constexpr (G_FUZZING_BUILD) {
+        return true;
+    } else if constexpr (!G_ABORT_ON_FAILED_ASSUME) {
+        // Running fuzz tests is always disabled if Assume() doesn't abort
+        // (ie, non-fuzz non-debug builds), as otherwise tests which
+        // should fail due to a failing Assume may still pass. As such,
+        // we also statically disable fuzz determinism in that case.
+        return false;
+    } else {
+        return g_enable_dynamic_fuzz_determinism;
+    }
+}
 
 std::string StrFormatInternalBug(std::string_view msg, std::string_view file, int line, std::string_view func);
 
@@ -50,11 +75,7 @@ void assertion_fail(std::string_view file, int line, std::string_view func, std:
 template <bool IS_ASSERT, typename T>
 constexpr T&& inline_assertion_check(LIFETIMEBOUND T&& val, [[maybe_unused]] const char* file, [[maybe_unused]] int line, [[maybe_unused]] const char* func, [[maybe_unused]] const char* assertion)
 {
-    if (IS_ASSERT || std::is_constant_evaluated() || G_FUZZING
-#ifdef ABORT_ON_FAILED_ASSUME
-        || true
-#endif
-    ) {
+    if (IS_ASSERT || std::is_constant_evaluated() || G_FUZZING_BUILD || G_ABORT_ON_FAILED_ASSUME) {
         if (!val) {
             assertion_fail(file, line, func, assertion);
         }