diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 9d8fdb4a16e..5cc1883dda2 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -242,6 +242,8 @@ jobs:
         working-directory: build
         env:
           QT_PLUGIN_PATH: '${{ github.workspace }}\build\vcpkg_installed\x64-windows\Qt6\plugins'
+          BITCOINUTIL: '${{ github.workspace }}\build\bin\Release\bitcoin-util.exe'
+          BITCOINTX: '${{ github.workspace }}\build\bin\Release\bitcoin-tx.exe'
         run: |
           ctest --output-on-failure --stop-on-failure -j $NUMBER_OF_PROCESSORS -C Release
 
diff --git a/CMakeLists.txt b/CMakeLists.txt
index 99490f742a6..24c6bfe0454 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -595,9 +595,7 @@ set(Python3_FIND_FRAMEWORK LAST CACHE STRING "")
 set(Python3_FIND_UNVERSIONED_NAMES FIRST CACHE STRING "")
 mark_as_advanced(Python3_FIND_FRAMEWORK Python3_FIND_UNVERSIONED_NAMES)
 find_package(Python3 3.10 COMPONENTS Interpreter)
-if(Python3_EXECUTABLE)
-  set(PYTHON_COMMAND ${Python3_EXECUTABLE})
-else()
+if(NOT TARGET Python3::Interpreter)
   list(APPEND configure_warnings
     "Minimum required Python not found. Utils and rpcauth tests are disabled."
   )
diff --git a/cmake/module/Maintenance.cmake b/cmake/module/Maintenance.cmake
index 4103c9b6383..b9960c67e1c 100644
--- a/cmake/module/Maintenance.cmake
+++ b/cmake/module/Maintenance.cmake
@@ -19,7 +19,7 @@ function(setup_split_debug_script)
 endfunction()
 
 function(add_maintenance_targets)
-  if(NOT PYTHON_COMMAND)
+  if(NOT TARGET Python3::Interpreter)
     return()
   endif()
 
@@ -31,13 +31,13 @@ function(add_maintenance_targets)
 
   add_custom_target(check-symbols
     COMMAND ${CMAKE_COMMAND} -E echo "Running symbol and dynamic library checks..."
-    COMMAND ${PYTHON_COMMAND} ${PROJECT_SOURCE_DIR}/contrib/devtools/symbol-check.py ${executables}
+    COMMAND Python3::Interpreter ${PROJECT_SOURCE_DIR}/contrib/devtools/symbol-check.py ${executables}
     VERBATIM
   )
 
   add_custom_target(check-security
     COMMAND ${CMAKE_COMMAND} -E echo "Checking binary security..."
-    COMMAND ${PYTHON_COMMAND} ${PROJECT_SOURCE_DIR}/contrib/devtools/security-check.py ${executables}
+    COMMAND Python3::Interpreter ${PROJECT_SOURCE_DIR}/contrib/devtools/security-check.py ${executables}
     VERBATIM
   )
 endfunction()
@@ -99,7 +99,7 @@ function(add_macos_deploy_target)
     if(CMAKE_HOST_APPLE)
       add_custom_command(
         OUTPUT ${PROJECT_BINARY_DIR}/${osx_volname}.zip
-        COMMAND ${PYTHON_COMMAND} ${PROJECT_SOURCE_DIR}/contrib/macdeploy/macdeployqtplus ${macos_app} ${osx_volname} -translations-dir=${QT_TRANSLATIONS_DIR} -zip
+        COMMAND Python3::Interpreter ${PROJECT_SOURCE_DIR}/contrib/macdeploy/macdeployqtplus ${macos_app} ${osx_volname} -translations-dir=${QT_TRANSLATIONS_DIR} -zip
         DEPENDS ${PROJECT_BINARY_DIR}/${macos_app}/Contents/MacOS/Bitcoin-Qt
         VERBATIM
       )
@@ -112,7 +112,7 @@ function(add_macos_deploy_target)
     else()
       add_custom_command(
         OUTPUT ${PROJECT_BINARY_DIR}/dist/${macos_app}/Contents/MacOS/Bitcoin-Qt
-        COMMAND OBJDUMP=${CMAKE_OBJDUMP} ${PYTHON_COMMAND} ${PROJECT_SOURCE_DIR}/contrib/macdeploy/macdeployqtplus ${macos_app} ${osx_volname} -translations-dir=${QT_TRANSLATIONS_DIR}
+        COMMAND ${CMAKE_COMMAND} -E env OBJDUMP=${CMAKE_OBJDUMP} $<TARGET_FILE:Python3::Interpreter> ${PROJECT_SOURCE_DIR}/contrib/macdeploy/macdeployqtplus ${macos_app} ${osx_volname} -translations-dir=${QT_TRANSLATIONS_DIR}
         DEPENDS ${PROJECT_BINARY_DIR}/${macos_app}/Contents/MacOS/Bitcoin-Qt
         VERBATIM
       )
diff --git a/cmake/tests.cmake b/cmake/tests.cmake
index 27913298001..7bab6a0c45f 100644
--- a/cmake/tests.cmake
+++ b/cmake/tests.cmake
@@ -2,14 +2,16 @@
 # Distributed under the MIT software license, see the accompanying
 # file COPYING or https://opensource.org/license/mit/.
 
-if(TARGET bitcoin-util AND TARGET bitcoin-tx AND PYTHON_COMMAND)
-  add_test(NAME util_test_runner
-    COMMAND ${CMAKE_COMMAND} -E env BITCOINUTIL=$<TARGET_FILE:bitcoin-util> BITCOINTX=$<TARGET_FILE:bitcoin-tx> ${PYTHON_COMMAND} ${PROJECT_BINARY_DIR}/test/util/test_runner.py
-  )
-endif()
+add_test(NAME util_test_runner
+  COMMAND Python3::Interpreter ${PROJECT_BINARY_DIR}/test/util/test_runner.py
+)
+set_tests_properties(util_test_runner PROPERTIES
+  DISABLED $<NOT:$<AND:$<TARGET_EXISTS:Python3::Interpreter>,$<TARGET_EXISTS:bitcoin-util>,$<TARGET_EXISTS:bitcoin-tx>>>
+)
 
-if(PYTHON_COMMAND)
-  add_test(NAME util_rpcauth_test
-    COMMAND ${PYTHON_COMMAND} ${PROJECT_BINARY_DIR}/test/util/rpcauth-test.py
-  )
-endif()
+add_test(NAME util_rpcauth_test
+  COMMAND Python3::Interpreter ${PROJECT_BINARY_DIR}/test/util/rpcauth-test.py
+)
+set_tests_properties(util_rpcauth_test PROPERTIES
+  DISABLED $<NOT:$<TARGET_EXISTS:Python3::Interpreter>>
+)
diff --git a/src/qt/CMakeLists.txt b/src/qt/CMakeLists.txt
index 7379a1f328e..98346f86b7b 100644
--- a/src/qt/CMakeLists.txt
+++ b/src/qt/CMakeLists.txt
@@ -348,7 +348,7 @@ else()
   get_translatable_sources(qt_translatable_sources src/qt)
   file(GLOB ui_files ${CMAKE_CURRENT_SOURCE_DIR}/forms/*.ui)
   add_custom_target(translate
-    COMMAND ${CMAKE_COMMAND} -E env XGETTEXT=${XGETTEXT_EXECUTABLE} COPYRIGHT_HOLDERS=${COPYRIGHT_HOLDERS} ${Python3_EXECUTABLE} ${PROJECT_SOURCE_DIR}/share/qt/extract_strings_qt.py ${translatable_sources}
+    COMMAND ${CMAKE_COMMAND} -E env XGETTEXT=${XGETTEXT_EXECUTABLE} COPYRIGHT_HOLDERS=${COPYRIGHT_HOLDERS} $<TARGET_FILE:Python3::Interpreter> ${PROJECT_SOURCE_DIR}/share/qt/extract_strings_qt.py ${translatable_sources}
     COMMAND Qt6::lupdate -no-obsolete -I ${PROJECT_SOURCE_DIR}/src -locations relative ${CMAKE_CURRENT_SOURCE_DIR}/bitcoinstrings.cpp ${ui_files} ${qt_translatable_sources} -ts ${CMAKE_CURRENT_SOURCE_DIR}/locale/bitcoin_en.ts
     COMMAND Qt6::lconvert -drop-translations -o ${CMAKE_CURRENT_SOURCE_DIR}/locale/bitcoin_en.xlf -i ${CMAKE_CURRENT_SOURCE_DIR}/locale/bitcoin_en.ts
     COMMAND ${SED_EXECUTABLE} -i.old -e "s|source-language=\"en\" target-language=\"en\"|source-language=\"en\"|" -e "/<target xml:space=\"preserve\"><\\/target>/d" ${CMAKE_CURRENT_SOURCE_DIR}/locale/bitcoin_en.xlf