diff --git a/src/rpc/mining.cpp b/src/rpc/mining.cpp
index 89f870d30e..e230281240 100644
--- a/src/rpc/mining.cpp
+++ b/src/rpc/mining.cpp
@@ -1,5 +1,5 @@
 // Copyright (c) 2010 Satoshi Nakamoto
-// Copyright (c) 2009-2022 The Bitcoin Core developers
+// Copyright (c) 2009-present The Bitcoin Core developers
 // Distributed under the MIT software license, see the accompanying
 // file COPYING or http://www.opensource.org/licenses/mit-license.php.
 
@@ -371,22 +371,22 @@ static RPCHelpMan generateblock()
 
     ChainstateManager& chainman = EnsureChainman(node);
     {
-        std::unique_ptr<BlockTemplate> block_template{miner.createNewBlock({.use_mempool = false, .coinbase_output_script = coinbase_output_script})};
-        CHECK_NONFATAL(block_template);
+        LOCK(chainman.GetMutex());
+        {
+            std::unique_ptr<BlockTemplate> block_template{miner.createNewBlock({.use_mempool = false, .coinbase_output_script = coinbase_output_script})};
+            CHECK_NONFATAL(block_template);
 
-        block = block_template->getBlock();
-    }
+            block = block_template->getBlock();
+        }
 
-    CHECK_NONFATAL(block.vtx.size() == 1);
+        CHECK_NONFATAL(block.vtx.size() == 1);
 
-    // Add transactions
-    block.vtx.insert(block.vtx.end(), txs.begin(), txs.end());
-    RegenerateCommitments(block, chainman);
+        // Add transactions
+        block.vtx.insert(block.vtx.end(), txs.begin(), txs.end());
+        RegenerateCommitments(block, chainman);
 
-    {
-        LOCK(::cs_main);
         BlockValidationState state;
-        if (!TestBlockValidity(state, chainman.GetParams(), chainman.ActiveChainstate(), block, chainman.m_blockman.LookupBlockIndex(block.hashPrevBlock),  /*fCheckPOW=*/false, /*fCheckMerkleRoot=*/false)) {
+        if (!TestBlockValidity(state, chainman.GetParams(), chainman.ActiveChainstate(), block, chainman.m_blockman.LookupBlockIndex(block.hashPrevBlock), /*fCheckPOW=*/false, /*fCheckMerkleRoot=*/false)) {
             throw JSONRPCError(RPC_VERIFY_ERROR, strprintf("TestBlockValidity failed: %s", state.ToString()));
         }
     }
diff --git a/test/functional/rpc_generate.py b/test/functional/rpc_generate.py
index 74f31f4571..618bbb2e00 100755
--- a/test/functional/rpc_generate.py
+++ b/test/functional/rpc_generate.py
@@ -1,9 +1,11 @@
 #!/usr/bin/env python3
-# Copyright (c) 2020-2022 The Bitcoin Core developers
+# Copyright (c) 2020-present The Bitcoin Core developers
 # Distributed under the MIT software license, see the accompanying
 # file COPYING or http://www.opensource.org/licenses/mit-license.php.
 """Test generate* RPCs."""
 
+from concurrent.futures import ThreadPoolExecutor
+
 from test_framework.test_framework import BitcoinTestFramework
 from test_framework.wallet import MiniWallet
 from test_framework.util import (
@@ -83,6 +85,13 @@ class RPCGenerateTest(BitcoinTestFramework):
         txid = block['tx'][1]
         assert_equal(node.getrawtransaction(txid=txid, verbose=False, blockhash=hash), rawtx)
 
+        # Ensure that generateblock can be called concurrently by many threads.
+        self.log.info('Generate blocks in parallel')
+        generate_50_blocks = lambda n: [n.generateblock(output=address, transactions=[]) for _ in range(50)]
+        rpcs = [node.cli for _ in range(6)]
+        with ThreadPoolExecutor(max_workers=len(rpcs)) as threads:
+            list(threads.map(generate_50_blocks, rpcs))
+
         self.log.info('Fail to generate block with out of order txs')
         txid1 = miniwallet.send_self_transfer(from_node=node)['txid']
         utxo1 = miniwallet.get_utxo(txid=txid1)