diff --git a/src/bitcoin-cli.cpp b/src/bitcoin-cli.cpp
index 934b5fb6dc1..7fcb4409314 100644
--- a/src/bitcoin-cli.cpp
+++ b/src/bitcoin-cli.cpp
@@ -87,10 +87,10 @@ static void SetupCliArgs(ArgsManager& argsman)
                              "arguments are number of blocks to generate (default: %s) and maximum iterations to try (default: %s), equivalent to "
                              "RPC generatetoaddress nblocks and maxtries arguments. Example: bitcoin-cli -generate 4 1000",
                              DEFAULT_NBLOCKS, DEFAULT_MAX_TRIES),
-                   ArgsManager::ALLOW_ANY, OptionsCategory::OPTIONS);
-    argsman.AddArg("-addrinfo", "Get the number of addresses known to the node, per network and total, after filtering for quality and recency. The total number of addresses known to the node may be higher.", ArgsManager::ALLOW_ANY, OptionsCategory::OPTIONS);
-    argsman.AddArg("-getinfo", "Get general information from the remote server. Note that unlike server-side RPC calls, the output of -getinfo is the result of multiple non-atomic requests. Some entries in the output may represent results from different states (e.g. wallet balance may be as of a different block from the chain state reported)", ArgsManager::ALLOW_ANY, OptionsCategory::OPTIONS);
-    argsman.AddArg("-netinfo", "Get network peer connection information from the remote server. An optional integer argument from 0 to 4 can be passed for different peers listings (default: 0). Pass \"help\" for detailed help documentation.", ArgsManager::ALLOW_ANY, OptionsCategory::OPTIONS);
+                   ArgsManager::ALLOW_ANY, OptionsCategory::CLI_COMMANDS);
+    argsman.AddArg("-addrinfo", "Get the number of addresses known to the node, per network and total, after filtering for quality and recency. The total number of addresses known to the node may be higher.", ArgsManager::ALLOW_ANY, OptionsCategory::CLI_COMMANDS);
+    argsman.AddArg("-getinfo", "Get general information from the remote server. Note that unlike server-side RPC calls, the output of -getinfo is the result of multiple non-atomic requests. Some entries in the output may represent results from different states (e.g. wallet balance may be as of a different block from the chain state reported)", ArgsManager::ALLOW_ANY, OptionsCategory::CLI_COMMANDS);
+    argsman.AddArg("-netinfo", "Get network peer connection information from the remote server. An optional integer argument from 0 to 4 can be passed for different peers listings (default: 0). Pass \"help\" for detailed help documentation.", ArgsManager::ALLOW_ANY, OptionsCategory::CLI_COMMANDS);
 
     SetupChainParamsBaseOptions(argsman);
     argsman.AddArg("-color=<when>", strprintf("Color setting for CLI output (default: %s). Valid values: always, auto (add color codes when standard output is connected to a terminal and OS is not WIN32), never.", DEFAULT_COLOR_SETTING), ArgsManager::ALLOW_ANY | ArgsManager::DISALLOW_NEGATION, OptionsCategory::OPTIONS);
@@ -1212,6 +1212,7 @@ static int CommandLineRPC(int argc, char *argv[])
                 fputc('\n', stdout);
             }
         }
+        gArgs.CheckMultipleCLIArgs();
         std::unique_ptr<BaseRequestHandler> rh;
         std::string method;
         if (gArgs.IsArgSet("-getinfo")) {
diff --git a/src/common/args.cpp b/src/common/args.cpp
index a37a16b62b0..9b3ad382963 100644
--- a/src/common/args.cpp
+++ b/src/common/args.cpp
@@ -16,6 +16,7 @@
 #include <util/fs.h>
 #include <util/fs_helpers.h>
 #include <util/strencodings.h>
+#include <util/string.h>
 
 #ifdef WIN32
 #include <codecvt>    /* for codecvt_utf8_utf16 */
@@ -588,6 +589,23 @@ void ArgsManager::AddHiddenArgs(const std::vector<std::string>& names)
     }
 }
 
+void ArgsManager::CheckMultipleCLIArgs() const
+{
+    LOCK(cs_args);
+    std::vector<std::string> found{};
+    auto cmds = m_available_args.find(OptionsCategory::CLI_COMMANDS);
+    if (cmds != m_available_args.end()) {
+        for (const auto& [cmd, argspec] : cmds->second) {
+            if (IsArgSet(cmd)) {
+                found.push_back(cmd);
+            }
+        }
+        if (found.size() > 1) {
+            throw std::runtime_error(strprintf("Only one of %s may be specified.", util::Join(found, ", ")));
+        }
+    }
+}
+
 std::string ArgsManager::GetHelpMessage() const
 {
     const bool show_debug = GetBoolArg("-help-debug", false);
@@ -635,6 +653,9 @@ std::string ArgsManager::GetHelpMessage() const
             case OptionsCategory::REGISTER_COMMANDS:
                 usage += HelpMessageGroup("Register Commands:");
                 break;
+            case OptionsCategory::CLI_COMMANDS:
+                usage += HelpMessageGroup("CLI Commands:");
+                break;
             default:
                 break;
         }
diff --git a/src/common/args.h b/src/common/args.h
index 323a86d8dca..3f4cbbfab46 100644
--- a/src/common/args.h
+++ b/src/common/args.h
@@ -63,6 +63,7 @@ enum class OptionsCategory {
     GUI,
     COMMANDS,
     REGISTER_COMMANDS,
+    CLI_COMMANDS,
 
     HIDDEN // Always the last option to avoid printing these in the help
 };
@@ -363,6 +364,13 @@ protected:
         m_network_only_args.clear();
     }
 
+    /**
+     * Check CLI command args
+     *
+     * @throws std::runtime_error when multiple CLI_COMMAND arguments are specified
+     */
+    void CheckMultipleCLIArgs() const;
+
     /**
      * Get the help string
      */
diff --git a/src/test/fuzz/system.cpp b/src/test/fuzz/system.cpp
index 73ae89b52a7..75f444e84f2 100644
--- a/src/test/fuzz/system.cpp
+++ b/src/test/fuzz/system.cpp
@@ -53,7 +53,7 @@ FUZZ_TARGET(system, .init = initialize_system)
                 args_manager.SoftSetBoolArg(fuzzed_data_provider.ConsumeRandomLengthString(16), fuzzed_data_provider.ConsumeBool());
             },
             [&] {
-                const OptionsCategory options_category = fuzzed_data_provider.PickValueInArray<OptionsCategory>({OptionsCategory::OPTIONS, OptionsCategory::CONNECTION, OptionsCategory::WALLET, OptionsCategory::WALLET_DEBUG_TEST, OptionsCategory::ZMQ, OptionsCategory::DEBUG_TEST, OptionsCategory::CHAINPARAMS, OptionsCategory::NODE_RELAY, OptionsCategory::BLOCK_CREATION, OptionsCategory::RPC, OptionsCategory::GUI, OptionsCategory::COMMANDS, OptionsCategory::REGISTER_COMMANDS, OptionsCategory::HIDDEN});
+                const OptionsCategory options_category = fuzzed_data_provider.PickValueInArray<OptionsCategory>({OptionsCategory::OPTIONS, OptionsCategory::CONNECTION, OptionsCategory::WALLET, OptionsCategory::WALLET_DEBUG_TEST, OptionsCategory::ZMQ, OptionsCategory::DEBUG_TEST, OptionsCategory::CHAINPARAMS, OptionsCategory::NODE_RELAY, OptionsCategory::BLOCK_CREATION, OptionsCategory::RPC, OptionsCategory::GUI, OptionsCategory::COMMANDS, OptionsCategory::REGISTER_COMMANDS, OptionsCategory::CLI_COMMANDS, OptionsCategory::HIDDEN});
                 // Avoid hitting:
                 // common/args.cpp:563: void ArgsManager::AddArg(const std::string &, const std::string &, unsigned int, const OptionsCategory &): Assertion `ret.second' failed.
                 const std::string argument_name = GetArgumentName(fuzzed_data_provider.ConsumeRandomLengthString(16));
diff --git a/test/functional/interface_bitcoin_cli.py b/test/functional/interface_bitcoin_cli.py
index e7113f8335d..30bf97185a1 100755
--- a/test/functional/interface_bitcoin_cli.py
+++ b/test/functional/interface_bitcoin_cli.py
@@ -381,6 +381,9 @@ class TestBitcoinCli(BitcoinTestFramework):
         assert_raises_process_error(1, "Could not connect to the server", self.nodes[0].cli('-rpcwait', '-rpcwaittimeout=5').echo)
         assert_greater_than_or_equal(time.time(), start_time + 5)
 
+        self.log.info("Test that only one of -addrinfo, -generate, -getinfo, -netinfo may be specified at a time")
+        assert_raises_process_error(1, "Only one of -getinfo, -netinfo may be specified", self.nodes[0].cli('-getinfo', '-netinfo').send_cli)
+
 
 if __name__ == '__main__':
     TestBitcoinCli(__file__).main()