diff --git a/src/test/pow_tests.cpp b/src/test/pow_tests.cpp
index edbc1de91f..76e4600441 100644
--- a/src/test/pow_tests.cpp
+++ b/src/test/pow_tests.cpp
@@ -177,7 +177,7 @@ void sanity_check_chainparams(const ArgsManager& args, ChainType chain_type)
 
     // check max target * 4*nPowTargetTimespan doesn't overflow -- see pow.cpp:CalculateNextWorkRequired()
     if (!consensus.fPowNoRetargeting) {
-        arith_uint256 targ_max{UintToArith256(uint256{"FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF"})};
+        arith_uint256 targ_max{UintToArith256(uint256{"ffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffff"})};
         targ_max /= consensus.nPowTargetTimespan*4;
         BOOST_CHECK(UintToArith256(consensus.powLimit) < targ_max);
     }
diff --git a/src/test/uint256_tests.cpp b/src/test/uint256_tests.cpp
index 4777f7ed47..8b76e0865a 100644
--- a/src/test/uint256_tests.cpp
+++ b/src/test/uint256_tests.cpp
@@ -431,7 +431,7 @@ BOOST_AUTO_TEST_CASE( check_ONE )
 BOOST_AUTO_TEST_CASE(FromHex_vs_uint256)
 {
     auto runtime_uint{uint256::FromHex("4A5E1E4BAAB89F3A32518A88C31BC87F618f76673e2cc77ab2127b7afdeda33b").value()};
-    constexpr uint256 consteval_uint{  "4a5e1e4baab89f3a32518a88c31bc87f618F76673E2CC77AB2127B7AFDEDA33B"};
+    constexpr uint256 consteval_uint{  "4a5e1e4baab89f3a32518a88c31bc87f618f76673e2cc77ab2127b7afdeda33b"};
     BOOST_CHECK_EQUAL(consteval_uint, runtime_uint);
 }
 
diff --git a/src/uint256.h b/src/uint256.h
index db37adfe6d..c7499c3f2c 100644
--- a/src/uint256.h
+++ b/src/uint256.h
@@ -130,13 +130,12 @@ consteval base_blob<BITS>::base_blob(std::string_view hex_str)
     // Non-lookup table version of HexDigit().
     auto from_hex = [](const char c) -> int8_t {
         if (c >= '0' && c <= '9') return c - '0';
-        if (c >= 'a' && c <= 'f') return c - 'a' + 0xA;
-        if (c >= 'A' && c <= 'F') return c - 'A' + 0xA;
+        if (c >= 'a' && c <= 'f') return c - 'a' + 0xa;
 
-        assert(false); // Reached if ctor is called with an invalid hex digit.
+        throw "Only lowercase hex digits are allowed, for consistency";
     };
 
-    assert(hex_str.length() == m_data.size() * 2); // 2 hex digits per byte.
+    if (hex_str.length() != m_data.size() * 2) throw "Hex string must fit exactly";
     auto str_it = hex_str.rbegin();
     for (auto& elem : m_data) {
         auto lo = from_hex(*(str_it++));