diff --git a/CMakeLists.txt b/CMakeLists.txt
index 114d46f71a5..bfcbd69430d 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -432,6 +432,10 @@ configure_file(contrib/filter-lcov.py filter-lcov.py USE_SOURCE_PERMISSIONS COPY
 # Don't allow extended (non-ASCII) symbols in identifiers. This is easier for code review.
 try_append_cxx_flags("-fno-extended-identifiers" TARGET core_interface SKIP_LINK)
 
+try_append_cxx_flags("-ffile-prefix-map=A=B" TARGET core_interface SKIP_LINK
+  IF_CHECK_PASSED "-ffile-prefix-map=${PROJECT_SOURCE_DIR}/src=."
+)
+
 # Currently all versions of gcc are subject to a class of bugs, see the
 # gccbug_90348 test case (only reproduces on GCC 11 and earlier) and
 # https://gcc.gnu.org/bugzilla/show_bug.cgi?id=111843. To work around that, set
diff --git a/cmake/ccache.cmake b/cmake/ccache.cmake
index 099aa66411f..d1cc204c8e4 100644
--- a/cmake/ccache.cmake
+++ b/cmake/ccache.cmake
@@ -23,14 +23,6 @@ if(NOT MSVC)
   else()
     set(WITH_CCACHE OFF)
   endif()
-  if(WITH_CCACHE)
-    try_append_cxx_flags("-fdebug-prefix-map=A=B" TARGET core_interface SKIP_LINK
-      IF_CHECK_PASSED "-fdebug-prefix-map=${PROJECT_SOURCE_DIR}=."
-    )
-    try_append_cxx_flags("-fmacro-prefix-map=A=B" TARGET core_interface SKIP_LINK
-      IF_CHECK_PASSED "-fmacro-prefix-map=${PROJECT_SOURCE_DIR}=."
-    )
-  endif()
 endif()
 
 mark_as_advanced(CCACHE_EXECUTABLE)
diff --git a/contrib/guix/libexec/build.sh b/contrib/guix/libexec/build.sh
index 3184cd4afe7..6c252e78702 100755
--- a/contrib/guix/libexec/build.sh
+++ b/contrib/guix/libexec/build.sh
@@ -212,7 +212,6 @@ CONFIGFLAGS="-DREDUCE_EXPORTS=ON -DBUILD_BENCH=OFF -DBUILD_GUI_TESTS=OFF -DBUILD
 HOST_CFLAGS="-O2 -g"
 HOST_CFLAGS+=$(find /gnu/store -maxdepth 1 -mindepth 1 -type d -exec echo -n " -ffile-prefix-map={}=/usr" \;)
 case "$HOST" in
-    *linux*)  HOST_CFLAGS+=" -ffile-prefix-map=${DISTSRC}/src=." ;;
     *mingw*)  HOST_CFLAGS+=" -fno-ident" ;;
     *darwin*) unset HOST_CFLAGS ;;
 esac