diff --git a/CMakeLists.txt b/CMakeLists.txt
index bbcedcec2d6..c5ebd2f04d5 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -346,13 +346,28 @@ target_link_libraries(core_interface INTERFACE
   Threads::Threads
 )
 
+# Define sanitize_interface with -fsanitize flags intended to apply to all
+# libraries and executables.
 add_library(sanitize_interface INTERFACE)
 target_link_libraries(core_interface INTERFACE sanitize_interface)
 if(SANITIZERS)
+  # Transform list of sanitizers into -fsanitize flags, replacing "fuzzer" with
+  # "fuzzer-no-link" in sanitize_interface flags, and moving "fuzzer" to
+  # fuzzer_interface flags. If -DSANITIZERS=fuzzer is specified, the fuzz test
+  # binary should be built with -fsanitize=fuzzer (so it can use libFuzzer's
+  # main function), but libraries should be built with -fsanitize=fuzzer-no-link
+  # (so they can be linked into other executables that have their own main
+  # functions).
+  string(REGEX REPLACE "(^|,)fuzzer($|,)" "\\1fuzzer-no-link\\2" sanitize_opts "${SANITIZERS}")
+  set(fuzz_flag "")
+  if(NOT sanitize_opts STREQUAL SANITIZERS)
+    set(fuzz_flag "-fsanitize=fuzzer")
+  endif()
+
   # First check if the compiler accepts flags. If an incompatible pair like
   # -fsanitize=address,thread is used here, this check will fail. This will also
   # fail if a bad argument is passed, e.g. -fsanitize=undfeined
-  try_append_cxx_flags("-fsanitize=${SANITIZERS}" TARGET sanitize_interface
+  try_append_cxx_flags("-fsanitize=${sanitize_opts}" TARGET sanitize_interface
     RESULT_VAR cxx_supports_sanitizers
     SKIP_LINK
   )
@@ -365,12 +380,11 @@ if(SANITIZERS)
   # flag. This is a separate check so we can give a better error message when
   # the sanitize flags are supported by the compiler but the actual sanitizer
   # libs are missing.
-  try_append_linker_flag("-fsanitize=${SANITIZERS}" VAR SANITIZER_LDFLAGS
+  try_append_linker_flag("-fsanitize=${sanitize_opts}" VAR SANITIZER_LDFLAGS
     SOURCE "
       #include <cstdint>
       #include <cstddef>
       extern \"C\" int LLVMFuzzerTestOneInput(const uint8_t* data, size_t size) { return 0; }
-      __attribute__((weak)) // allow for libFuzzer linking
       int main() { return 0; }
     "
     RESULT_VAR linker_supports_sanitizers
@@ -382,8 +396,10 @@ if(SANITIZERS)
 endif()
 target_link_options(sanitize_interface INTERFACE ${SANITIZER_LDFLAGS})
 
+# Define fuzzer_interface with flags intended to apply to the fuzz test binary,
+# and perform a test compilation to determine correct value of
+# FUZZ_BINARY_LINKS_WITHOUT_MAIN_FUNCTION.
 if(BUILD_FUZZ_BINARY)
-  target_link_libraries(core_interface INTERFACE ${FUZZ_LIBS})
   include(CheckSourceCompilesWithFlags)
   check_cxx_source_compiles_with_flags("
       #include <cstdint>
@@ -391,9 +407,12 @@ if(BUILD_FUZZ_BINARY)
       extern \"C\" int LLVMFuzzerTestOneInput(const uint8_t* data, size_t size) { return 0; }
       // No main() function.
     " FUZZ_BINARY_LINKS_WITHOUT_MAIN_FUNCTION
-    LDFLAGS ${SANITIZER_LDFLAGS}
+    LDFLAGS ${SANITIZER_LDFLAGS} ${fuzz_flag}
     LINK_LIBRARIES ${FUZZ_LIBS}
   )
+  add_library(fuzzer_interface INTERFACE)
+  target_link_options(fuzzer_interface INTERFACE ${fuzz_flag})
+  target_link_libraries(fuzzer_interface INTERFACE ${FUZZ_LIBS})
 endif()
 
 include(AddBoostIfNeeded)
diff --git a/src/test/fuzz/CMakeLists.txt b/src/test/fuzz/CMakeLists.txt
index 846afeeb474..64fbe69dc00 100644
--- a/src/test/fuzz/CMakeLists.txt
+++ b/src/test/fuzz/CMakeLists.txt
@@ -138,6 +138,7 @@ add_executable(fuzz
 )
 target_link_libraries(fuzz
   core_interface
+  fuzzer_interface
   test_fuzz
   bitcoin_cli
   bitcoin_common