diff --git a/CMakeLists.txt b/CMakeLists.txt
index 4b21646ca1..2dba6f255d 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -298,6 +298,15 @@ if(WIN32)
     try_append_linker_flag("-Wl,--major-subsystem-version,6" TARGET core_interface)
     try_append_linker_flag("-Wl,--minor-subsystem-version,2" TARGET core_interface)
   endif()
+
+  # Workaround producing large object files, which cannot be handled by the assembler.
+  # More likely to happen with no, or lower levels of optimisation.
+  # See discussion in https://github.com/bitcoin/bitcoin/issues/28109.
+  if(CMAKE_CXX_COMPILER_ID STREQUAL "MSVC")
+    try_append_cxx_flags("/bigobj" TARGET core_interface_debug SKIP_LINK)
+  else()
+    try_append_cxx_flags("-Wa,-mbig-obj" TARGET core_interface_debug SKIP_LINK)
+  endif()
 endif()
 
 # Use 64-bit off_t on 32-bit Linux.